telomeres telomerase cellular aging and immortality
| PAG Title | telomeres telomerase cellular aging and immortality |
| PAG ID | WAG000241 |
| Type | P |
| Source Link |  BioCarta |
| Publication Reference | NA |
| PAG Description | Telomeres, which define the ends of chromosomes, consist of short, tandemly repeated D sequences loosely conserved in eukaryotes. Telomerase is a ribonucleoprotein complex ( we only show a few of the components in this illustration) which in vitro recognizes a single-stranded G-rich telomere primer and adds multiple telomeric repeats to its 3-prime end by using an R template. Telomerase may also have a role in de novo formation of telomeres. Telomerase has been identified in many cultured cell lines and actively dividing cell types. The active reverse transcriptase component has been identified in teh TERT protein. The presence of this factor determines the availability of the telomerase function. The TERT protein has a high turnover rate and its expression is regulated by factors that promote growth (c-MYC, v-k-ras, Bcl-2 and E6) and inhibiting factors (RB and p53) that promote cell death or that block cell division. It appears that the regulation of active telomerase has many levels and can be inhibited by TEP1 not releasing TERT or by TRF1 which binds the end repeats and prevents access to the chromosome ends. Additiol modulation is due to phosphorlyation by PKC and AKT or dephophorylation by PP2A. |
| Species | Homo sapiens |
| nCoCo Score | 1,220 |
| Base PAG ID | WAG000241 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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